Sepsis can be a final common pathway in disease progression irrespective of the pathogen causing infection. The role of emerging infectious diseases that can lead to sepsis will be discussed in this presentation. Sepsis should be considered in any emerging infectious disease response, including assessment for needed escalation of care and identification of at-risk patients. Medical countermeasures that address sepsis are, by definition, an important part of emerging infectious disease preparedness and include host-based diagnostics and improved patient management strategies. The historical role of coronaviruses, including SARS-CoV-2, and other emerging pathogens and their clinical implications with respect to sepsis will be reviewed.

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